Infectious Disease

Dengue Fever — Clinical Reference

Last reviewed 2026-06-19 · TruelyserMD Clinical Reference
For Patients & General Readers

Dengue fever is a viral illness spread by mosquitoes, most commonly in tropical and subtropical regions. It can cause flu-like symptoms, and in some cases, can develop into a severe and life-threatening condition. Early recognition and proper management are crucial for preventing severe complications.

Clinical Overview

Dengue fever is a systemic viral infection caused by four serotypes of the dengue virus (DENV-1, DENV-2, DENV-3, DENV-4), transmitted by Aedes mosquitoes. It presents with a wide spectrum of illness, ranging from asymptomatic infection to severe dengue, characterized by plasma leakage, hemorrhage, or organ impairment.

Clinical Presentation

Signs & Symptoms

Symptoms (Patient-Reported)

  • High fever
  • Severe headache
  • Pain behind the eyes
  • Muscle aches
  • Joint pain
  • Nausea
  • Vomiting
  • Rash
  • Fatigue

Signs (Clinician-Observed)

  • Fever
  • Tachycardia
  • Hypotension (in severe cases)
  • Petechiae or purpura
  • Positive tourniquet test (in some cases)

Differential Diagnoses

ConditionDistinguishing Feature
Chikungunya FeverMore pronounced and persistent joint pain, often with swelling, and less frequently associated with hemorrhagic manifestations.
Zika Virus InfectionMilder symptoms, often with conjunctivitis and a characteristic rash that may appear earlier. Less risk of severe disease.
MalariaCyclical fever patterns, chills, and rigors. Diagnosis confirmed by peripheral blood smear or rapid diagnostic tests.
InfluenzaRespiratory symptoms are more prominent. Dengue typically lacks significant upper respiratory tract involvement.
LeptospirosisCan present with fever, myalgia, and headache. Jaundice, conjunctival suffusion, and renal involvement are more common in leptospirosis.
Typhoid FeverGradual onset of fever, abdominal pain, and constipation or diarrhea. Rose spots may be present. Blood cultures are diagnostic.

Red Flags — Seek Immediate Care

Key Investigations

Management Overview

Management of dengue fever is primarily supportive, focusing on fluid resuscitation to prevent or manage plasma leakage and shock. Careful monitoring for warning signs of severe dengue is essential, with prompt escalation of care for patients exhibiting these indicators. Antipyretics like paracetamol are recommended, while NSAIDs should be avoided due to increased bleeding risk.

Disclaimer: This article is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional for diagnosis and treatment. TruelyserMD does not replace clinical judgement.